Cancer Research Overview

Having gained a better understanding of the phenolic compounds found in mangos, the National Mango Board commissioned a cell culture study to determine whether mangos possess properties that might help to reduce the incidence of cancer and other diseases. Drs. Stephen and Susanne Talcott of Texas A&M University, College Station, Texas, studied the antioxidants in mangos to help determine how bioactive compounds from mangos are broken down and absorbed.

They initially tested the activity of these mango antioxidants against several types of cancer cells: colon cancer, lung cancer, breast cancer, prostate cancer and leukemia in a controlled lab environment. Because the colon can absorb nutrients in two ways – from the bloodstream and from direct contact with the intestines – polyphenols are more likely to be absorbed in the colon than in other areas. (Cells in the lungs, breasts or prostate, for example, only have access to antioxidants through the bloodstream). Based on these initial findings, the researchers opted to focus their research on mango and colon cancer.

The study reports posted below outline the exciting results of this preliminary in vitro study. Based on the promising findings of the cell study, the NMB is currently pursuing a human clinical trial in volunteers with inflammatory bowel disease and related conditions to study the possible beneficial effects of mango supplementation.

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