Nutrition & Health Research

The Nutrition and Health program is designed to provide information about the phytochemical compounds and nutritive value of the main mango varieties consumed in the U.S. and its relation with human health. It includes the following projects:

Breast Cancer Preliminary Human Study 

  • Obtain preliminary data with very few patients or patient samples which can be used to propose a larger study with mangos 
  • Propose a large scale human clinical trial not only to the NMB but also NIH, Susan G. Komen Foundation, CDC, ACS and other organizations which provide funding for cancer studies
  • Ongoing project from 2013

Colon Cancer Human Study 

  • Understand whether mango pulp is capable of suppressing colon cancer development through its effects on the regulation of colon epithelial cell number
  • Ongoing project from 2013

Diabetes Human Study

  • Improving glucose tolerance 
  • Reducing body fat
  • Attenuating biomarkers of oxidative stress (lipid peroxidation, LDL oxidation, myeloperoxidase) 
  • Modulating other clinical (i.e. lipid profile) in prediabetic subjects 
  • Ongoing project from 2013

Colon Cell Absorption Human Study

  • Determine the absorption of different polyphenolics from mango using specific colon cell layers and different mango varieties in order to assess absorbable and non-absorbable fractions
  • Ongoing project from 2013

Digestion Human Study

  • Investigate the effects of regular mango consumption on digestion in population with frequent constipation
  • Ongoing project from 2014

Diabetes Animal Study

  • Investigate the effects of dietary supplementation of mango on gut-mediated immunity and microbiome and the corresponding changes in glucose homeostasis and body composition in an animal model of diet-induced obesity
  • Ongoing project from 2014                                                                                                  

Mango and Glucose Response

  • Examine the effectiveness of mango in modulating post-prandial stress responses (hyperglycemia, hyperlipidemia, oxidative stress, and inflammation)after a high fat meal

Metabolism and Cell Culture

  • Generate intestinal metabolites by A) incubating mango polyphenols with fecal material from pigs and humans to, B) Chemically characterize the metabolites and C) assess their anti-inflammatory activities in cell culture

Fiber Composition Project

  • Undertake a fiber analysis to know the amount and types of soluble and insoluble fiber in the main mango varieties marketed in U.S., and the amount and composition of the prebiotic fibers that may be present in the main mango varieties marketed in U.S.

Nutrition Science Advisor

  • Maintain ongoing communication with NMB researchers at Texas A&M University, Oklahoma State University and other universities that partner with the NMB for research efforts
    Engage in monthly status update teleconferences with researchers on current ongoing projects
  • Quarterly update of research trackers
  • Obtain conference materials as needed
  • Work directly with researchers and universities’ PR departments on press release approvals
  • Assist the NMB’s Director of Research in doing and evaluating research proposals received 
All nutrition studies funded by the NMB use mangos that are readily available to U.S. consumers, meaning that common varieties and hot water treated mangos are used.
The discovery of new, positive health benefits from eating mangos could have a major impact on future mango sales. In this age of health-conscious consumers, nutrition messages are extremely powerful as a marketing tool. Consumers are hungry for news about how to stay healthier longer. Combined with the delicious flavor of mangos, nutrition messages may be a big win for the mango industry.
 
Check out the related research links below for the latest results from the NMB’s nutrition research program. For each project, a detailed project report is posted, along with an easy-to-read executive summary.
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