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Exploring the Phytochemicals
Glucose and Lipid Parameters
Cancer Cell Study
Bone Parameters
Cancer Human Study
Exploring the phytochemicals in imported mangos
Conducted By: United States Department of Agriculture–Agricultural Research Service, Lane, OK.
Principal Investigator: Dr. Penelope Perkins-Veazie
Time line: 4/1/2006 – 8/31/2008
Objectives:
- Identify the variations in phytochemicals/antioxidants among all the varieties of mangos imported and sold in the U.S. and tested at the eating ripeness stage
- Provide the groundwork for future medical studies and provide solid data for use in marketing, labeling and promotion of mangos as a part of a healthy diet
Click here for the executive summary
Click here for the report
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Mango modulates glucose and lipid parameters in high fat diet-induced obesity
Conducted By: Oklahoma State University – United States Department of Agriculture–Agricultural Research Service, Lane, OK.
Principal Investigator: Dr. Edralin Lucas
Time line: 10/23/2007 – 4/30/2010
Objectives:
- Investigate the effect of freeze dried mango on glucose and lipid parameters in high fat diet-induced obesity
- Positive results will help understand the hypoglycemic and hypolipidemic mechanisms of action of mango and may justify pursuing human clinical studies
Click here for the executive summary
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Phytochemical attributes contribute to the health-promoting benefits of mangos
Conducted By: Texas A & M University
Principal Investigator: Drs. Stephen and Susanne Talcott
Time line: 1/29/2008 – 3/31/2009
Objectives:
- Investigate six (6) mango cultivars in six (6) common cancer cell lines (lung, prostate, breast, pancreas, blood, and colon)
- Evaluate a dose-response (i.e., consumption level) in conjunction with extracts containing compounds with different molecular weights (i.e. digestion effects)
- Evaluate absorption characteristics (using a model of human colon cells) of the phytochemicals in mangoes (emphasis on polyphenolics) in attempt to simulate compound absorption into the human body
Click here for the executive summary
Click here for the report
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Effect of mangos in bone parameters in high fat diet – induced obesity
Conducted by: Oklahoma State University in collaboration with USDA_ARS, OK
Principal Investigator: Dr. Edralin Lucas
Time line: 10/2/2008 – 12/31/2010
Objectives:
- Examine the effects of mango on bone mass using a bone densitometer.
- Evaluate the effects of mango on bone microarchitecture using X-ray microcomputed tomography.
- Determine the effects of mango on bone strength using simulated compression testing.
- Assess the effects of freeze-dried mango on bone metabolism using biomarkers of bone formation and bone resorption and steady-state mRNA expression of indicators of bone metabolism.
Project report will be posted when available.
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Beneficial Effects of Mango Fruit in the Prevention of Cancer
Conducted by: Texas A&M University
Principal Investigators: Drs. Susanne and Stephen Talcott
Time line: 3/30/2010 – 12/31/2010
Objectives:
- Perform a human clinical mango consumption trial in volunteers with inflammatory bowel disease and related conditions to study the possible beneficial effect of mango
- Obtain preliminary findings on whether mango pulp is capable of suppressing certain risk factors for colon cancer development through its effects on the regulation of colon epithelial cell number
Project report will be posted when available.
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